[1][2] In one small study, women given promethazine with meperidine and secobarbital during labor, had the time to lactogenesis II prolonged by 14 hours. Your dosage, drug form, and how often you take the drug will depend on:It has not been confirmed that promethazine is safe and effective for use in children younger than 2 years.The liver, kidneys, and hearts of older adults may not work as well as they used to. Examples of these drugs include:Promethazine can cause severe drowsiness. It may help with some symptoms associated with the common cold. Promethazine antagonizes the central and peripheral effects of histamine mediated by histamine H1 receptors. This increases your risk of side effects.Your doctor may start you on a lower dose or a different medication schedule. Make sure you tell your doctor if you have any other medical problems, especially:Portions of this document last updated: Aug. 01, 2020Copyright © 2020 IBM Watson Health. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional.Written by University of Illinois-Chicago, Drug Information GroupWritten by University of Illinois-Chicago, Drug Information Group Because promethazine can lower basal prolactin secretion, promethazine might interfere with the establishment of lactation if given during labor, before lactation is well established or with a sympathomimetic such as pseudoephedrine. This increases your risk of side effects.Your doctor may start you on a lower dose or a different medication schedule. All rights reserved. Examples of these drugs include:When you take certain stomach and gastrointestinal drugs with promethazine, certain side effects may increase and last longer. It comes with risks if you don’t take it as prescribed.If you’re taking this drug to prevent or treat nausea and vomiting, motion sickness, pain, or to lessen anxiety and promote sleep, you may not experience relief of your symptoms.If you think you’ve taken too much of this drug, call your doctor or seek guidance from the American Association of Poison Control Centers at 800-222-1222 or through their Keep these considerations in mind if your doctor prescribes promethazine for you.A prescription for this medication is refillable.

Talk to your doctor about other drug options that may work for you.© 2004-2020 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company.

When you take certain pain drugs with promethazine, you may have drowsiness that is more extreme and lasts longer. Select one or more newsletters to continue. When you take certain muscle relaxants with promethazine, you may have drowsiness that is more extreme and lasts longer. Available for Android and iOS devices.Messinis IE, Souvatzoglou A, Fais N et al. This is a decision you and your doctor will make. Advertising revenue supports our not-for-profit mission.Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. For treatment of nausea and vomiting, promethazine is usually taken every 4 to 6 hours as needed. Examples of these drugs include:Promethazine can cause severe drowsiness. This can cause your body to process drugs more slowly. Examples of these drugs include:When you take certain Parkinson’s disease drugs with promethazine, some side effects may increase and last longer. For prevention of motion sickness, promethazine is usually taken 30-60 minutes before departure, and then every 12 hours as needed. Promethazine has not been studied for use while breastfeeding.