The Giants beat the Bills 20-19.

Bill Kostroun New York won 38-21. (AP Photo/David Duprey)New York Giants' Osi Umenyiora (72) celebrates a Giants interception and touchdown during the second half of the NFL football game against the Buffalo Bills at Ralph Wilson Stadium in Orchard Park, N.Y., Sunday, Dec. 23, 2007. (AP Photo/Bill Kostroun)New York Giants' Corey Webster (23) is helped up by teammates after intercepting a pass during the fourth quarter of an NFL football game against the Buffalo Bills Sunday, Oct. 16, 2011, in East Rutherford, N.J. New York won 38-21. (AP Photo)Joe Danelo of the New York Giants follows through, left, as his kick sails over the outstretched arms of Buffalo Bills players to win Monday, Aug. 29, 1977 exhibition game 24-21 in sudden death overtime in East Rutherford, N.J. (AP Photo/Olga Shalygin)New York Giant running back Ottis Anderson (24) is brought down the hard way during the fourth quarter of Super Bowl XXV Sunday, Jan. 27, 1991 in Tampa. (AP Photo/David Duprey)Buffalo Bills kicker Rian Lindell, far right, kicks a field goal during the second quarter of an NFL football game against the New York Giants on Sunday, Oct. 16, 2011, in East Rutherford, N.J. (AP Photo/Julio Cortez)New York Giants' Ahmad Bradshaw (44) scores a touchdown over the Buffalo Bills during the third quarter of an NFL football game Sunday, Oct. 16, 2011, in East Rutherford, N.J. (AP Photo/Julio Cortez)New York Giants cornerback Corey Webster (23) intercepts a pass intended for Buffalo Bills wide receiver Steve Johnson during the fourth quarter of an NFL football game on Sunday, Oct. 16, 2011, in East Rutherford, N.J. Johnson was called for a face mask on the play.

The New York Giants (0-1) host the Buffalo Bills (1-0) at MetLife Stadium in the Giants’ 2019 home opener.The Giants are coming off a disappointing loss in Week 1 down in Dallas, while the Bills will be returning to the same venue they played in last week when they came back to beat the Jets, 17-16.Here are six things to know about this week’s matchup:This will be the 13th time since the 1970 merger the Giants have played the Bills in the regular season. (AP Photo/Bill Kostroun)New York Giants running back Ahmad Bradshaw (44) runs past Buffalo Bills cornerback Drayton Florence (29) during the first quarter of an NFL football game on Sunday, Oct. 16, 2011, in East Rutherford, N.J. (AP Photo/Julio Cortez)New York Giants wide receiver Rueben Randle (82) reacts after scoring a touchdown on a pass from quarterback Eli Manning as Buffalo Bills cornerback Stephon Gilmore, left, and strong safety Bacarri Rambo look on during the first half of an NFL football game, Sunday, Oct. 4, 2015, in Orchard Park, N.Y. (AP Photo/Bill Wippert)New York Giants running back Rashad Jennings, right, looks at Buffalo Bills cornerback Ronald Darby, left, as he scores on a touchdown run during the second half of an NFL football game, Sunday, Oct. 4, 2015, in Orchard Park, N.Y. (AP Photo/Gary Wiepert)New York Giants quarterback Eli Manning (10) talks to his teammates during the first half of an NFL football game against the Buffalo Bills, Sunday, Oct. 4, 2015, in Orchard Park, N.Y. (AP Photo/Bill Wippert)Photos from the career of two-time Super Bowl MVP quarterback Eli ManningHere is a photo from every one of Eli Manning's starts over his 16-year careerView photos of the first pair of brothers to play quarterback in a Super Bowl.View photos of Giants who have been tagged in the past.The Giants remember the legacy of Del Shofner, one of the NFL's top receivers of his time.We take a look at past compensatory draft picks by the New York Giants.
All Rights Reserved. (AP Photo/David Duprey)New York Giants' Kawika Mitchell (55) celebrates his interception for a touchdown during the second half of the NFL football game against the Buffalo Bills at Ralph Wilson Stadium in Orchard Park, N.Y., Sunday, Dec. 23, 2007. (AP Photo/Bill Waugh)Buffalo Bills kicker Scott Norwood (11) walks off the field in dejection after missing a 47-yard field goal on the last play of the game, clinching a 20-19 victory for the New York Giants in Super Bowl XXV in Tampa, Fla., Jan. 27, 1991. The Giants won 20-19. NFL's Greatest Games is a series of television programs that air on NFL Network, ESPN and related networks. (AP Photo/Don Heupel)New York Giants' Brandon Jacobs (27) scores a touchdown under pressure from Buffalo Bills' John DiGiorgio (52) during the second quarter of their NFL football game at Ralph Wilson Stadium in Orchard Park, N.Y., Sunday, Dec. 23, 2007.

Julio Cortez (During Buffalo's final drive, ABC put up a graphic that showed Norwood's career history of field goal attempts of 40+ yards on grass fields; he was 1 for 5) Norwood's kick sailed There were many impressive performances in the game by players from both teams. Buffalo then took over and stormed down the field, advancing 63 yards in just four plays and scoring on a 31-yard burst from running back On the Bills' final possession, Kelly led the team down the field with a mix of scrambles, short passes, and Thomas runs, of which the last was for a healthy, and very critical, seven yards, managing to get the Bills to the Giants 29-yard line, just within field goal range with eight seconds to play.

The Giants came out on top to win the Super Bowl 20-19 in Tampa Sunday, Jan. 27, 1991.

Fredrickson made gain of 2 yards on the play as New York won, 20-8. The two teams have met each other 174 times (including 4 postseason games), with the New York Giants winning 85 games and the Philadelphia Eagles winning 87 games. © 2018 New York Giants. https://giantswire.usatoday.com/2019/09/11/new-york-giants-buffalo-bills-6-things-know-week-2/
The Giants hold the slight advantage with a 7-6 record.